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phenobarbital will lower the level or impact of olanzapine/samidorphan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Potent CYP3A4 inducers decrease amounts of olanzapine and samidorphan by~50% and ~75% respectively.phenobarbital will minimize the extent or outcome of mavacamten by affecting hepatic/intest